Recent Publications

Anxiolytic Efficacy of Indirubin: In Vivo Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways

 

Journal name: Journal of ChemistryOpen

Publication Year: 2024

Authors: Ishrat Jahan Disha, Rubel Hasan, Md. Shimul Bhuia, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam

Abstract

Anxiety is a natural response to stress, characterized by feelings of worry, fear, or unease. The current research was conducted to investigate the anxiolytic effect of indirubin (IND) in different behavioral paradigms in Swiss albino mice. To observe the animal's behavioural response to assess anxiolytic activity, different tests were performed, such as the open‐field (square cross, grooming, and rearing), swing, dark‐light, and hole cross tests. The experimental mice were administered IND (5 and 10 mg/kg, p.o.), where diazepam (DZP) and vehicle were used as positive and negative controls, respectively. In addition, a combination treatment (DZP+IND‐10) was provided to the animals to determine the modulatory effect of IND on DZP. Molecular docking approach was also conducted to determine the binding energy of IND with the GABAA receptor (α2 and α3 subunits) and pharmacokinetics were also estimated. The findings revealed that IND dose‐dependently significantly (p<0.05) reduced the animal's movement exerting calming behavior like DZP. IND also demonstrated the highest docking score (−7.7 kcal/mol) against the α3 subunit, while DZP showed a lower docking value (−6.4 kcal/mol) than IND. The ADMET analysis revealed that IND has proper drug‐likeness and pharmacokinetic characteristics. In conclusion, IND exerted anxiolytic effects through GABAergic Pathways.

Botanical Sources, Pharmacokinetics, and Therapeutic Efficacy of Palmatine and Its Derivatives in the Management of Cancer: A Comprehensive Mechanistic Analysis

 

Journal name: Journal of Food Biochemistry 

Publication Year: 2024

Authors: Most. Israt Jahan Oni, Md. Shimul Bhuia, Raihan Chowdhury, Salehin Sheikh, Md. Sakib Al Munshi, Md. Hanif, Hasan, Muhammad Torequl Islam

Abstract

Natural compounds and their derivatives have been identified as valuable sources of therapeutic ingredients for cancer treatment. The naturally occurring phytochemical palmatine (isoquinoline alkaloid) is extracted from plant parts (rhizomes, roots, stems, stem barks, and others) and has protective effects including antioxidant, anti-inflammatory, and anticancer. This study aims to summarize the anticancer potential of palmatine and its derivatives in the treatment of numerous types of cancer with molecular mechanisms. We also include the pharmacokinetic features, botanical origin, and toxicological characteristics of palmatine and its derivatives. For this, data have been collected from plausible different electronic databases, including PubMed, Google Scholar, PubChem, Science Direct, Web of Science, Scopus, Springer Link, and Wiley Online. The findings demonstrate that palmatine and its derivatives have a protective anticancer effect against a variety of cancers, including breast, colorectal, gastric, ovarian, prostate, pancreatic, skin, hepatocellular cancer, and mammary gland tumors. They provoke their anticancer properties against various cancer cell lines via modifying molecular mechanisms like induction of oxidative stress, cytotoxicity, apoptosis, inhibition of cell invasion and migration, arresting the cell cycle at the S phase, antiproliferative, and antiangiogenic effects. It is suggested that palmatine and its derivatives may be a good option in the development of novel drugs for cancer therapy in the future

Abietic acid antagonizes the anti-inflammatory effects of celecoxib and ketoprofen: Preclinical assessment and molecular dynamic simulations

 

Journal name: Computers in Biology and Medicine

Publication Year: 2024

Authors: Rubel Hasan, Md Shimul Bhuia, Raihan Chowdhury, Sajib Saha, Muhammad Ali Khan, Meher Afroz, Siddique Akber Ansari, Irfan Aamer Ansari, Henrique Douglas Melo Coutinho, Muhammad Torequl Islam

Abstract

The present work is designed to explore the anti-inflammatory properties of AA and its modulatory effects on celecoxib (CEL) and ketoprofen (KET) through in vitro, ex vivo, in vivo, and in silico approaches. Different concentrations of AA were utilized to evaluate the membrane-stabilizing potential via egg albumin and the Human Red Blood Cell (HRBC) denaturation model. In the animal model, formalin (50 μL) was injected into the right hind paw of young chicks to induce inflammation. AA was administered at 20 and 40 mg/kg (p.o.) to the experimental animals. We used CEL and KET as positive controls. The vehicle was provided as a control group. Two combinations of AA with CEL and KET were also investigated in all tests to assess the modulatory activity of AA. In addition, in silico investigation was used for predictions about drug-likeness, pharmacokinetics, and toxicity of the selected chemical compounds, and the study also evaluated the binding affinity, visualization, and stability of ligand-receptor interactions through molecular dynamic (MD) simulation. Results manifested that AA concentration-dependently significantly inhibited the egg albumin denaturation (IC50: 27.53 ± 0.88 μg/ml) and breakdown of HRBC (IC50: 15.69 ± 0.75 μg/ml), indicating the membrane stabilizing potential compared to the control group. AA also significantly (p < 0.05) lessened the frequency of licking and alleviated the paw edema in a dose-dependent manner in an in vivo test. However, AA reduced the activity of CEL and KET in combination treatment. AA showed good pharmacokinetic characteristics to be considered as a therapeutic candidate. Additionally, the in silico study displayed that AA demonstrated a relatively higher docking score of −9.1 kcal/mol with the cyclooxygenase-2 (COX-2) enzyme and stable binding in MD simulation. Whereas the standard ligand (CEL) expressed the highest binding value of −9.2 kcal/mol to the COX-2.

Anticancer activity of Nigella sativa and its bioactive compounds: An update

 

Journal name: Journal of Pharmacological Research-Natural Products

Publication Year: 2024

Authors: Mst Asma Aktar, Md Shimul Bhuia, Raihan Chowdhury, Shrabonti Biswas, Mst Rifah Sanzida, Fatema Akter Sonia, Jannatul Ferdous, Razina Rouf, Mohammad S Mubarak, Lucia Raquel de Lima, Henrique Douglas Melo Coutinho, Edinardo FF Matias, João Paulo Martins Lima, Janini Filgueira Rosas, Muhammad Torequl Islam

Abstract

Nigella sativa (black cumin) is a widely recognized medicinal plant in traditional medicine, and its seeds and seed oil are used in the treatment of various diseases. This plant and its bioactive compounds exhibit numerous biological activities such as anti-diabetic, anticancer, antimicrobial, and anti-inflammatory, among others. N. sativa contains many bioactive compounds, including important antineoplastic agents such as thymoquinone, α-hederin, carvacrol, and thymol. This review focuses on and discusses the medicinal and health-promoting effects of N. sativa and covers the recent developments that deal with the anticancer activity of this medicinal plant and its bioactive compounds, with an emphasis on the mechanism of action. The findings demonstrated that the preventive effect of N. sativaand its bioactive phytochemicals are associated with its ability to decrease inflammation and exert immune-enhancing actions. The plant and its phytochemicals also enhance natural killer (NK) cell cytotoxicity, apoptotic effects on carcinoma cells, and control signal transduction pathways including caspases, p53, ROS, AMPK/mTOR, NF-κB, JAK2/STAT3, and PI3K/Akt in suppressing cancer and tumorigenesis. However, this suggests the use of the plant as a chemotherapeutic agent and further clinical assessment of the bioactive phytochemicals to establish a reliable anticancer drug.

Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono- or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms

 

Journal name: Journal of Tropical Medicine

Publication Year: 2024

Authors: Tanzila Akter Eity, Md. Shimul Bhuia, Raihan Chowdhury, Shakil Ahmmed, Salehin Sheikh, Rima Akter, Muhammad Torequl Islam

Abstract

Quercetin, a major representative of the flavonol subclass found abundantly in almost all edible vegetables and fruits, showed remarkable therapeutic properties and was beneficial in numerous degenerative diseases by preventing lipid peroxidation. Quercetin is beneficial in different diseases, such as atherosclerosis and chronic inflammation. This study aims to find out the anticancer activities of quercetin and to determine different mechanisms and pathways which are responsible for the anticancer effect. It also revealed the biopharmaceutical, toxicological characteristics, and clinical utilization of quercetin to evaluate its suitability for further investigations as a reliable anticancer drug. All of the relevant data concerning this compound with cancer was collected using different scientific search engines, including PubMed, Springer Link, Wiley Online, Web of Science, SciFinder, ScienceDirect, and Google Scholar. This review demonstrated that quercetin showed strong anticancer properties, including apoptosis, inhibition of cell proliferation, autophagy, cell cycle arrest, inhibition of angiogenesis, and inhibition of invasion and migration against various types of cancer. Findings also revealed that quercetin could significantly moderate and regulate different pathways, including PI3K/AKT-mTORC1 pathway, JAK/STAT signaling system, MAPK signaling pathway, MMP signaling pathway, NF-κB pathway, and p-Camk2/p-DRP1 pathway. However, this study found that quercetin showed poor oral bioavailability due to reduced absorption; this limitation is overcome by applying nanotechnology (nanoformulation of quercetin). Moreover, different investigations revealed that quercetin expressed no toxic effect in the investigated subjects. Based on the view of these findings, it is demonstrated that quercetin might be considered a reliable chemotherapeutic drug candidate in the treatment of different cancers. However, more clinical studies are suggested to establish the proper therapeutic efficacy, safety, and human dose.

Modulatory Sedative Activity of Abrine on Diazepam in Thiopental Sodium Mediated Sleeping Mice: An In Vivo Approach with Receptor Binding Affinity of GABAergic Transmission

 

Journal name: Journal of ChemistrySelect

Publication Year: 2024

Authors: Jannatul Ferdous, Md. Shimul Bhuia, Raihan Chowdhury, Salehin Sheikh, Siddique Akber Ansari, Mehedi Hasan Bappi, Muhammad Torequl Islam

Abstract

The current study aims to assess the effects of abrine (ABR) in thiopental sodium (TS)-induced sleeping mice and to explore the sedative impacts of the compound by using in vivo and in silico investigations. ABR (5 and 10 mg k−1g, i.p.) and diazepam (DZP) (2 mg k−1g, i.p.) were administered to the experimental animals either single or combined. TS (20 mg k−1g, i.p.) was administered to induce sleep, and latency with sleeping duration was observed for 3 h. The in silico investigation was conducted to predict the role of ABR in the gamma-aminobutyric acid A (GABAA) receptor in the sleeping process and to evaluate pharmacokinetics and toxicity. Results showed that ABR (10 mg k−1g) significantly (p < 0.05) decreased the latency period (8.20 ± 1.85 min) and enhanced sleep duration (187.8 ± 8.87 min) in comparison with the control group. Additionally, the co-treatments of ABR and DZP remarkably reduced the latency period (4.40 ± 0.24 min) and increased the sleeping duration (201.40 ± 5.89 min) compared to the single therapy. The molecular docking indicated that ABR has a binding affinity of −7.4 kcal/mol for the GABAA receptor. In conclusion, ABR provides strong sedative and synergistic efficacy on TS-induced sleeping mice via the GABAergic system.

Anxiolytic Efficacy of Indirubin: In Vivo Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways

 

Journal name: Journal of ChemistryOpen

Publication Year: 2024

Authors: Ishrat Jahan Disha, Rubel Hasan, Md. Shimul Bhuia, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam

Abstract

Anxiety is a natural response to stress, characterized by feelings of worry, fear, or unease. The current research was conducted to investigate the anxiolytic effect of indirubin (IND) in different behavioral paradigms in Swiss albino mice. To observe the animal's behavioural response to assess anxiolytic activity, different tests were performed, such as the open‐field (square cross, grooming, and rearing), swing, dark‐light, and hole cross tests. The experimental mice were administered IND (5 and 10 mg/kg, p.o.), where diazepam (DZP) and vehicle were used as positive and negative controls, respectively. In addition, a combination treatment (DZP+IND‐10) was provided to the animals to determine the modulatory effect of IND on DZP. Molecular docking approach was also conducted to determine the binding energy of IND with the GABAA receptor (α2 and α3 subunits) and pharmacokinetics were also estimated. The findings revealed that IND dose‐dependently significantly (p<0.05) reduced the animal's movement exerting calming behavior like DZP. IND also demonstrated the highest docking score (−7.7 kcal/mol) against the α3 subunit, while DZP showed a lower docking value (−6.4 kcal/mol) than IND. The ADMET analysis revealed that IND has proper drug‐likeness and pharmacokinetic characteristics. In conclusion, IND exerted anxiolytic effects through GABAergic Pathways.

Anxiolytic Efficacy of Indirubin: In Vivo Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways

 

Journal name: Journal of ChemistryOpen

Publication Year: 2024

Authors: Ishrat Jahan Disha, Rubel Hasan, Md. Shimul Bhuia, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam

Abstract

Anxiety is a natural response to stress, characterized by feelings of worry, fear, or unease. The current research was conducted to investigate the anxiolytic effect of indirubin (IND) in different behavioral paradigms in Swiss albino mice. To observe the animal's behavioural response to assess anxiolytic activity, different tests were performed, such as the open‐field (square cross, grooming, and rearing), swing, dark‐light, and hole cross tests. The experimental mice were administered IND (5 and 10 mg/kg, p.o.), where diazepam (DZP) and vehicle were used as positive and negative controls, respectively. In addition, a combination treatment (DZP+IND‐10) was provided to the animals to determine the modulatory effect of IND on DZP. Molecular docking approach was also conducted to determine the binding energy of IND with the GABAA receptor (α2 and α3 subunits) and pharmacokinetics were also estimated. The findings revealed that IND dose‐dependently significantly (p<0.05) reduced the animal's movement exerting calming behavior like DZP. IND also demonstrated the highest docking score (−7.7 kcal/mol) against the α3 subunit, while DZP showed a lower docking value (−6.4 kcal/mol) than IND. The ADMET analysis revealed that IND has proper drug‐likeness and pharmacokinetic characteristics. In conclusion, IND exerted anxiolytic effects through GABAergic Pathways.

List of Publications- 2025

 

  1. Bhuia, M.S., Chowdhury, Raihan., Afroz, M., Akbor, M.S., Hasan, M.S.A., Ferdous, J., Hasan, R., Alencar, M.V.O.B., Mubarak, M.S., & Islam, M.T. (2025). Therapeutic Efficacy Studies on the Monoterpenoid Hinokitiol in the Treatment of Different Types of Cancer. Chemistry & Biodiversity, 2024, e202401904. https://doi.org/10.1002/cbdv.202401904

 

 

 

List of Publications- 2024

 

  1. Islam, M.T., Bhuia, M.S., Mostakim, M.S., Chowdhury, R., Hasan, R., Sheikh, S., Ansari, S.A., Ansari, I.A., Eity, T.A. & Islam, M.T. (2025). Synergistic Anxiolytic Effects of Linalool and Sesamol Co‐Treatment on Swiss Albino Mice: A Potential GABAergic Intervention. Synapse, 79(1), p.e70003. https://doi.org/10.1002/syn.70003 (IF: 1.6, Q4)

  2. Chowdhury, R., Bhuia, M.S., Rakib, A.I., Sheikh, S., Ahmmed, S., Situ, S.G., Ansari, S.A., Ansari, I.A. & Islam, M.T. (2024). (±) Citronellal Exerts Antidepressant and Modulatory Effects on Duloxetine Possibly Through Serotonin and Norepinephrine Reuptake Interaction Pathway: In Vivo Approach with Molecular Docking. ChemistrySelect, 9(46), p.e202404764. https://doi.org/10.1002/slct.202404764 (IF: 1.9, CS: 3.3, Q3) 
  3. Al Hasan, M. S., Bhuia, M. S., Sheikh, S., Bithi, S. A., Saim, M. A., Kamli, H., Ansari, S. A., Ahammed, N. T., & Islam, M. T. (2024). Assessment of sedative activity of Chrysin: Behavioral approach with pharmacokinetics, toxicological profile and molecular docking. Sleep medicine, 126, 88–96. https://doi.org/10.1016/j.sleep.2024.12.007 (IF: 3.8, Q1)
  4. Islam, M. T., Malik, A., Alshememry, A. K., Chowdhury, R., Bhuia, M. S., Fatima, S., Hossen, M. S., Rakib, A. I., Mollah, F., Akbor, M. S., Bappi, M. H., Saim, M. A., & Islam, M. T. (2024). Anxiolytic Effect of Sesamol, Possibly Through the GABAkine Interaction Pathway. Drug development research, 85(8), e70028. https://doi.org/10.1002/ddr.70028 (IF: 3.5, CS: 6.4, Q2)
  5. Yadav, S. N., Al Hasan, M. S., Das, B., Shadin, M., Rakib, I. H., Rohan, F., Ansari, S.A., Ansari, I.A., Bhuia, M.S., Lima, M.A., Domiciano, C.B., Coutinho, H.D.M., & Islam, M. T. (2024). Assessment of clot-lysing and membrane-stabilizing capacity of ascorbic acid: in vitro approach with molecular docking. Toxicology Reports, 13, 101831. https://doi.org/10.1016/j.toxrep.2024.101831 (CS: 7.6)
  6. Al Hasan, M. S., Mia, E., Yana, N. T., Rakib, I. H., Bhuia, M. S., Chowdhury, R., S, S., & Islam, M. T. (2024). Allium cepa bioactive phytochemicals as potent ALK (Anaplastic lymphoma kinase) inhibitors and therapeutic agents against non-small cell lung cancer (NSCLC): a computational Study. Pharmacological Research-Natural Products, 5, 100124. https://doi.org/10.1016/j.prenap.2024.100124
  7. Husain, Z., Saifiuzzaman, M., Bhuia, M. S., Ferdous, J., Al Hasan, M. S., Bappi, M. H., Akbor, M.S., Ansari, S.A., Ansari, I.A., Islam, M.A., & Islam, M. T. (2024). Tangeretin exerts and modulates the anxiolytic effects of the GABAkine drugs diazepam and flumazenil in mice: molecular interventions through animal behaviour and molecular dynamic simulations. Food Bioscience, 62, 105469. https://doi.org/10.1016/j.fbio.2024.105469 (IF: 4.8, CS: 6.4, Q1)
  8. Bhuia, M. S., Al Hasan, M. S., Chowdhury, R., Ansari, S. A., Ansari, I. A., & Islam, M. T. (2024). Trans-Ferulic acid reduces the sedative activity of diazepam in thiopental sodium-induced sleeping mice: A potential GABAergic transmission. Neurotoxicology and teratology, 106, 107403. https://doi.org/10.1016/j.ntt.2024.107403 (IF: 2.6, CS: 5.6, Q1)
  9. Situ, S.G., Bhuia, M.S., Chowdhury, R., Hasan, M.S.A., Ansari, S.A., Ansari, I.A., Ali, M.A., & Islam, M.T. (2024). Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: In Vivo and in Silico Investigations on Receptor Binding Affinity. ChemistryOpen, e202400345. https://doi.org/10.1002/open.202400345 (IF: 2.5, CS: 4.8, Q2)
  10. Rakib, A.I., Sheikh, S., Chowdhury, R., Bhuia, M.S., Hasan, M.S.A., Ansari, S.A., Ansari, I.A., & Islam, M.T. (2024). Qualitative Phytochemical Analysis and Assessments of Analgesic and Antidiarrheal Activity of the Methanolic Leaf Extract of Cheilanthes tenuifolia: In Vivo Study. Immunity, inflammation and disease, 12 (11), e70055. https://doi.org/10.1002/iid3.70055 (IF: 3.1, CS: 3.6, Q3)
  11. Jahan Oni, M. I., Bhuia, M. S., Chowdhury, R., Sheikh, S., Munshi, M. H., Hasan, M. S. A., & Islam, M. T. (2024). Botanical Sources, Pharmacokinetics, and Therapeutic Efficacy of Palmatine and Its Derivatives in the Management of Cancer: A Comprehensive Mechanistic Analysis. Journal of Food Biochemistry, 2024(1), 8843855. https://doi.org/10.1155/2024/8843855 (IF: 3.5, Q2)
  12. Hasan, R., Bhuia, M. S., Chowdhury, R., Saha, S., Khan, M. A., Afroz, M., Ansari, S. A., Ansari, I. A., Melo Coutinho, H. D., & Islam, M. T. (2024). Abietic acid antagonizes the anti-inflammatory effects of celecoxib and ketoprofen: Preclinical assessment and molecular dynamic simulations. Computers in biology and medicine, 183, 109298. Advance online publication. https://doi.org/10.1016/j.compbiomed.2024.109298 (IF: 7, CS: 11.7, Q1)
  13. El-Nashar, H. A., Elhawary, E. A., Al-Qaaneh, A. M., Bhuia, M. S., Chowdhury, R., Abdel-Maksoud, M., Malik, A., Islam, M.T., & Aufy, M. (2024). UPLC-ESI/MS n Metabolic Profiling of Cedrela odorata L. and Toona ciliata M. Roem and in vitro Investigation of their Anti-diabetic Activity Supported with Molecular Docking Studies. Frontiers in Chemistry, 12, 1462309. https://doi.org/10.3389/fchem.2024.1462309 (IF: 3.8, Q2)
  14. Hasan, R., Bhuia, M. S., Chowdhury, R., Khan, M. A., Mazumder, M., Yana, N. T., Alencar, M. V. O. B., Ansari, S. A., Ansari, I. A., & Islam, M. T. (2024). Piperine exerts anti-inflammatory effects and antagonises the properties of celecoxib and ketoprofen: in vivo and molecular docking studies. Natural product research, 1–16. Advance online publication. https://doi.org/10.1080/14786419.2024.2413039 (IF: 1.9, CS: 5.1, Q3)
  15. Aktar, M. A., Bhuia, M. S., Chowdhury, R., Biswas, S., Sanzida, M. R., Sonia, F. A., Ferdous, J., Rouf, R., Mubarak, M.S., de Lima, L.R., Coutinho, H.D.M., Matias, E.F.F., Lima, J.P.M., Rosas, J.F., & Islam, M. T. (2024). Anticancer activity of Nigella sativa and its bioactive compounds: An update. Pharmacological Research-Natural Products, 5, 100100. https://doi.org/10.1016/j.prenap.2024.100100
  16. Eity, T. A., Bhuia, M. S., Chowdhury, R., Ahmmed, S., Salehin Sheikh, Akter, R., & Islam, M. T. (2024). Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono- or Com           bination Therapies in the Management of Cancer: An Update with Molecular Mechanisms. Journal of tropical medicine, 2024, 5594462. https://doi.org/10.1155/2024/5594462 (IF: 2.1, CS: 3.9, Q2)
  17. Ferdous, J., Bhuia, M. S., Chowdhury, R., Sheikh, S., Ansari, S. A., Bappi, M. H., & Islam, M. T. (2024). Modulatory Sedative Activity of Abrine on Diazepam in Thiopental Sodium Mediated Sleeping Mice: An In Vivo Approach with Receptor Binding Affinity of GABAergic Transmission. ChemistrySelect, 9(37), e202403725. https://doi.org/10.1002/slct.202403725 (IF: 1.9, CS: 3.3, Q3)
  18. Disha, I. J., Hasan, R., Bhuia, S., Ansari, S. A., Ansari, I. A., & Islam, M. T. (2024). Anxiolytic Efficacy of Indirubin: In Vivo Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways. ChemistryOpen, e202400290. Advance online publication. https://doi.org/10.1002/open.202400290 (IF: 2.5, CS: 4.8, Q2)
  19. Saim, M. A., Bhuia, M. S., Eity, T. A., Chowdhury, R., Ahammed, N. T., Ansari, S. A., Hossain, K. N., Luna, A. A., Munshi, M. H., & Islam, M. T. (2024). Assessment of antiemetic activity of dihydrocoumarin: In vivo and in silico approaches on receptor binding affinity and   modulatory effects. Journal of pharmacological and toxicological methods, 130, 107561. Advance online publication. https://doi.org/10.1016/j.vascn.2024.107561 (IF: 1.3, CS: 3.6, Q4)
  20. Islam, M.T., Iriti, M., Harhar, H., Elouafy, Y., Bhuia, M.S., Chamkhi, I., Gürer, E.S., & Sharifi-Rad, J. (2024). Evaluation of toxic effects of rabeprazole sodium on the plant-based eukaryotic test models. Vitae, 31(2). https://doi.org/10.17533/udea.vitae.v31n2a352429
  21. Islam, M. T., Prottay, A. A. S., Akbor, M. S., Bhuia, M. S., Islam, M. A., & Saifiuzzaman, M. (2024). Anxiolytic-like effect of daidzin possibly through GABAA receptor α2 and α3 subunits interaction pathway: in vivo and in silico studies. Pharmacological Research-Natural Products, 5, 100090. https://doi.org/10.1016/j.prenap.2024.100090
  22. Rokonuzzman, M., Bhuia, M. S., Al-Qaaneh, A. M., El-Nashar, H. A. S., Islam, T., Chowdhury, R., Shanto, H. H., Al Hasan, M. S., El-Shazly, M., & Islam, M. T. (2024). Biomedical Perspectives of Citronellal: Biological Activities, Toxicological Profile and Molecular Mechanisms. Chemistry & biodiversity, e202401973. https://doi.org/10.1002/cbdv.202401973  (IF: 2.3, CS: 3.6, Q3)
  23. Islam, M. T., Bhuia, M. S., Sheikh, S., Hasan, R., Bappi, M. H., Chowdhury, R., Ansari, S. A., Islam, M. A., & Saifuzzaman, M. (2024). Sedative Effects of Daidzin, Possibly Through the GABAA Receptor Interaction Pathway: In Vivo Approach with Molecular Dynamic Simulations. Journal of molecular neuroscience: MN, 74(3), 83. https://doi.org/10.1007/s12031-024-02261-z (IF: 2.8, Q2)
  24. Islam, M. T., Chowdhury, R., Bhuia, M. S., Chakrabarty, B., Kundu, N., Akbor, M. S., Sheikh, S., Chowdhury, R. I., Ansari, S. A., Ansari, I. A., & Islam, M. A. (2024). Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5-HT2A and D2 receptor interaction pathways. Drug development research, 85(6), e22259. https://doi.org/10.1002/ddr.22259 (IF: 3.5, CS: 6.4, Q2)
  25. Mukty, S. A., Hasan, R., Bhuia, M. S., Saha, A. K., Rahman, U. S., Khatun, M. M., Bithi, S. A., Ansari, S. A., Ansari, I. A., & Islam, M. T. (2024). Assessment of sedative activity of fraxin: In vivo approach along with receptor binding affinity and molecular interaction with GABAergic system. Drug development research, 85(6), e22250. https://doi.org/10.1002/ddr.22250 (IF: 3.5, CS: 6.4, Q2)
  26. Aktar, M. A., Bhuia, M. S., Chowdhury, R., Ferdous, J., Khatun, M. M., Al Hasan, M. S., Mia, E., Hasan, R., & Islam, M. T. (2024). An Insight of Plant Source, Toxicological Profile, and Pharmacological Activities of Iridoid Loganic Acid: A Comprehensive Review. Chemistry & biodiversity, e202400874. Advance online publication. https://doi.org/10.1002/cbdv.202400874 (IF: 2.3, CS: 3.6, Q3)
  27. Aktar, M. A., Bhuia, M. S., Molla, S., Chowdhury, R., Sarkar, C., Al Shahariar, M., Roy, P., Reiner, Ž., Sharifi‑Rad, J., Calina, D., Shakil, M.A.K.,  & Islam, M. T. (2024). Pharmacological and phytochemical review of Acmella oleracea: a comprehensive analysis of its therapeutic potential. Discover Applied Sciences, 6(8), 412. http://dx.doi.org/10.1007/s42452-024-06108-5 (Q1, IF: 2.8, Q2)
  28. Khatun, M.M., Bhuia, M.S., Chowdhury, R., Sheikh, S., Ajmee, A., Mollah, F., Hasan, M.S.A., Coutinho, H.D.M., & Islam, M.T. (2024). Potential utilization of ferulic acid and its derivatives in the management of metabolic diseases and disorders: An insight into mechanisms. Cellular Signaling, 2024 (121), 111291. https://doi.org/10.1016/j.cellsig.2024.111291 (IF: 4.4, CS: 8.2, Q2)
  29. Chowdhury, R., Bhuia, M.S., Hasan, M.S.A., Snigdha, S.H., Afrin, S., Büsselberg, D., Habtemariam, S., Gürer, E.S., Sharifi-Rad, J., Aldahish, A.A., Аkhtayeva, N., & Islam, M.T. (2024). Anticancer potential of phytochemicals derived from mangrove plants: comprehensive mechanistic insights. Food Science and Nutrition, 2024 (2024), 4318. http://dx.doi.org/10.1002/fsn3.4318 (IF: 3.5, CS: 7.4, Q2)
  30. Islam, M. T., Chowdhury, R., Al Hasan, M. S., Sheikh, S., Bhuia, M. S., Bithi, S. A., Oni, M.I.J., Bappi, M.H., Ansari, S.A., Lucetti, E.C. & Tahim, C.M. (2024). Possible hemoglobin enhancing effect of phytol in methotrexate-induced folate deficient Swiss albino mice: In vivo and in silico studies. Pharmaceutical Science Advances, 2024 (2), 100043. http://dx.doi.org/10.1016/j.pscia.2024.100043
  31. Chowdhury, R., Bhuia, M. S., Wilairatana, P., Afroz, M., Hasan, R., Ferdous, J., Rakib, A.I., Sheikh, S., Mubarak, M.S., & Islam, M. T. (2024). An insight into the anticancer potentials of lignan arctiin: A comprehensive review of molecular mechanisms. Heliyon, 10 (12), e32899. http://dx.doi.org/10.1016/j.heliyon.2024.e32899 (IF: 3.4, Q1)
  32. Islam, M. T., Bappi, M. H., Bhuia, M. S., Ansari, S. A., Ansari, I. A., Shill, M. C., Tala, A., Saleh, N., El-Shazly, M., & El-Nashar, H. A. (2024). Anti-inflammatory effects of thymol: an emphasis on the molecular interactions through in vivo approach and molecular dynamic simulations. Frontiers in Chemistry, 12, 1376783. http://dx.doi.org/10.3389/fchem.2024.1376783 (IF: 3.8, CS: 8.5, Q2)
  33. Bhuia, M. S., Chowdhury, R., Shill, M. C., Chowdhury, A. K., Coutinho, H. D. M., Antas E Silva, D., Raposo, A., & Islam, M. T. (2024). Therapeutic Promises of Ferulic Acid and its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms. Chemistry & biodiversity, e202400443. https://doi.org/10.1002/cbdv.202400443 (IF: 2.3, CS: 3.6, Q3)
  34. Aktar, A., Bhuia, M.S., Chowdhury, R., Hasan, R., Islam Rakib, A., Al Hasan, S., Akter Sonia, F., & Torequl Islam, M. (2024). Therapeutic Promises of Bioactive Rosavin: A Comprehensive Review with Mechanistic Insight. Chemistry & biodiversity, e202400286. https://doi.org/10.1002/cbdv.202400286 (IF: 2.3, CS: 3.4, Q2)
  35. Bhuia, M. S., Chowdhury, R., Akter, M. A., Ali, M. A., Afroz, M., Akbor, M. S., Sonia, F. A., Mubarak, M. S., & Islam, M. T. (2024). A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives. Phytotherapy research: PTR, 38(8), 3877–3898. https://doi.org/10.1002/ptr.8239 (IF: 6.1, CS: 12.8, Q1)
  36. Chowdhury, R., Bhuia, S., Rakib, A. I., Al Hasan, S., Shill, M. C., El-Nashar, H. A. S., El-Shazly, M., & Islam, M. T. (2024). Gigantol, a promising natural drug for inflammation: a literature review and computational based study. Natural product research, 1–17. Advance online publication. https://doi.org/10.1080/14786419.2024.2340042. (IF: 1.9, CS: 5.1, Q3)
  37. Hasan, R., Alshammari, A., Albekairi, N. A., Bhuia, M. S., Afroz, M., Chowdhury, R., Khan, M. A., Ansari, S. A., Ansari, I. A., Mubarak, M. S., & Islam, M. T. (2024). Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways. Scientific reports, 14(1), 6642. https://doi.org/10.1038/s41598-024-57173-0 (IF: 3.8, Q1)
  38. Ferdous, J., Bhuia, M. S., Chowdhury, R., Rakib, A. I., Aktar, M. A., Al Hasan, M. S., Melo Coutinho, H. D., & Islam, M. T. (2024). Pharmacological Activities of Plant-Derived Fraxin with Molecular Mechanisms: A Comprehensive Review. Chemistry & biodiversity, 21(5), e202301615. https://doi.org/10.1002/cbdv.20230161.  (IF: 2.3, CS: 3.6, Q3)
  39. Bhuia, M.S., Chowdhury, R., Ara, I., Mamun, M., Rouf, R., Khan, M.A., Uddin, S.J., Shakil, M.A.K., Habtemariam, S., Ferdous, J., Calina, D., Sharifi-Rad, J., & Islam, M.T. (2024). Bioactivities of morroniside: A comprehensive review of pharmacological properties and molecular mechanisms, Fitoterapia, 174 (2024), 105896. https://doi.org/10.1016/j.fitote.2024.105896 (IF: 2.5, Q3)
  40. Juhi, U.H., El-Nashar, H.A.S., Faruq, A.A., Bhuia, M.S., Sultana, I., Alam, S., Saleh, N., El-Shazly, M., & Islam, M.T. (2024). Phytochemical Analysis and Biological Investigation of Cheilanthes tenuifolia (Burm.f.) Swartz. Frontiers in Pharmacology, 15(2024), 1366889. https://doi.org/10.3389/fphar.2024.1366889 (IF: 4.4, Q1)
  41. Chowdhury, R., Bhuia, M.S., Hasan, M.S.A., Ansari, S.A., Ansari, I.A., Gurgel, A.P.A.D., Coutinho, H.D.M., & Islam, M.T. (2024). Anticonvulsant effect of (±) citronellal possibly through the GABAergic and voltage-gated sodium channel receptor interaction pathways: in vivo and in silico studies. Neurochemistry International, 175 (2024), 105704. https://doi.org/10.1016/j.neuint.2024.105704 (IF: 4.4, Q1).
  42. Shill, M. C., El-Nashar, H. A. S., Mollick, P. P., Acharyya, R. N., Afrin, S., Hossain, H., Halder, S., Islam, M. T., Bhuia, M. S., Reza, H. M., El-Shazly, M., & Mubarak, M. S. (2024). Longevity spinach (Gynura procumbens) ameliorated oxidative stress and inflammatory mediators in cisplatin-induced organ dysfunction in rats: comprehensive in vivo and in silico studies. Chemistry & biodiversity, e202301719. https://doi.org/10.1002/cbdv.202301719. (IF: 2.3, CS: 3.6, Q3)
  43. Biswas, S., Smrity, S.Z., Bhuia, M.S., Sonia, F.A., Aktar, M.A., Chowdhury, R., Islam, T., Islam, M.T., Gonçalves Alencar, G., Paulo, C.L.R., Gurgel, A.P.A.D & Coutinho, H.D.M. (2024). Beta-Thalassemia: A Pharmacological Drug-Based Treatment. Drugs Drug Candidates, 3, 126-147. https://doi.org/10.3390/ddc3010008
  44. Chandra Shill, M., All Rakib, A., Islam Khan, S., Hossain, M., Alam, S., Hossain, H., Karmakar, U.K., Bhuia, M.S., Shahriar, M., Reza, H.M., Sarkar, C., Gürer, E.S., Sharifi-Rad, J., Butnariu, M., & Islam, M.T. (2024). Polyphenol-Standardized Aphanamixis polystachya Leaf Extract Ameliorates Diabetes, Oxidative Stress, Inflammation, and Fibrosis in Streptozotocin-Induced Diabetic Rats. Journal of Food Biochemistry, 2024, 9441968. https://doi.org/10.1155/2024/9441968 (IF: 3.5, Q2)
  45. Afroz, M., Bhuia, M. S., Rahman, M. A., Hasan, R., Islam, T., Islam, M. R., Chowdhury, R., Khan, M. A., Antas E Silva, D., Melo Coutinho, H. D., & Islam, M. T. (2024). Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies. European journal of pharmacology, 965, 176289. https://doi.org/10.1016/j.ejphar.2023.176289 (IF: 4.2, CS: 9.0, Q1)
  46. Bhuia, M. S., Chowdhury, R., Sonia, F. A., Biswas, S., Ferdous, J., El-Nashar, H. A. S., El-Shazly, M., & Islam, M. T. (2024). Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature-Based Study. Chemistry & biodiversity, 21(2), e202301492. https://doi.org/10.1002/cbdv.202301492  (IF: 2.3, CS: 3.6, Q3)

List of Publications- 2023

  1. Chowdhury, R., Bhuia, M. S., Rakib, A. I., Hasan, R., Coutinho, H. D. M., Araújo, I. M., de Menezes, I. R. A., & Islam, M. T. (2023). Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects. Plants (Basel, Switzerland), 12(24), 4189. https://doi.org/10.3390/plants12244189. (IF:4.0; CS: 6.5, Q1)
  2. Prottay, A. A. S., Bappi, M. H., Akbor, M. S., Asha, A. I., Bhuia, M. S., Shafin, A. A.,  Mia, M.N., Mubarak, M.S., de Azevedo Lima, M., Coutinho, H.D.M., & Islam, M. T. (2023). Sclareol exerts an anti-inflammatory effect, possibly through COXs inhibition pathway: In vivo and in silico studies. Pharmaceutical Science Advances, 100029. https://doi.org/10.1016/j.pscia.2023.100029
  3. Bhuia, M.S., Aktar, a, M.A., Chowdhury, R., Ferdous, J., Rahman, M.A., Hasan, M.S.A., & Islam, M.T. (2023). Therapeutic potentials of ononin with mechanistic insights: A comprehensive review. Food Bioscience, 63(2023), 103302. https://doi.org/10.1016/j.fbio.2023.103302 (IF: 4.8 CS: 6.4, Q1)
  4. Khan, M. A., El-Kersh, D. M., Islam, M.S., Khan, S. A., Kamli, H., Sarkar, C., Bhuia, M. S., Islam, T., Shill, M. C., Gobe, G. C., Gürer, E. S., Setzer, W. N., Sharifi-Rad, J., & Islam, M. T. (2023). Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential. Chemistry and biodiversity, e202300392. https://doi.org/10.1002/cbdv.202300392 (IF: 2.3, CS: 3.6, Q3)
  5. Bhuia, M.S., Rokonuzzman, M., Hossain, M.I., Ansari, S.A., Ansari, I.A., Islam, T., Al Hasan, M.S., Mubarak, M.S., & Islam, M.T. (2023). Anxiolytic-like Effects by trans-Ferulic Acid Possibly Occur through GABAergic Interaction Pathways. Pharmaceuticals, 16, 1271. https://doi.org/10.3390/ph16091271 (IF: 4.3, CS: 6.1, Q1)
  6. Islam, M.T., Bhuia, M.S., de Lima, J.P.M., Maia, F.P.A., Ducati, A.B.H., & Coutinho, H.D.M. (2023). Phytanic acid, an inconclusive phytol metabolite: A review. Current Research in Toxicology, 100120. https://doi.org/10.1016/j.crtox.2023.100120 (IF: 2.9 CS: 4.7, Q2)
  7. Bhuia, M.S., Wilairatana, P., Ferdous, J., Chowdhury, R., Bappi, M.H., Rahman, M.A., Mubarak, M.S., & Islam, M.T. (2023). Hirsutine, an Emerging Natural Product with Promising Therapeutic Benefits: A Systematic Review. Molecules, 28, 6141. https://doi.org/10.3390/molecules28166141 (IF: 4.2, Q2)
  8. Bhuia, M.S., Chowdhury, R., Sonia, F.A., Kamli, H., Shaikh, A., El-Nashar, H. A. S., El-Shazly, M., & Islam. M.T. (2023). Anticancer Potential of the Plant-Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches. Chemistry and biodiversity, 20(9), e202300847. https://doi.org/10.1002/cbdv.202300847 (IF: 2.3, CS: 3.6, Q3)
  9. Bhuia, M. S., Kamli, H., Islam, T., Sonia, F. A., Kazi, M. A., Siam, M. S. H., Rahman, N., Bappi, M.H., Mia, M.N., Hossen, M.M., Lucetti, D.L., Oliveira, P.L.C., Coutinho, H.D.M., & Islam, M. T. (2023). Antiemetic activity of trans-ferulic acid possibly through muscarinic receptors interaction pathway: In vivo and in silico study. Results in Chemistry, 101014. https://doi.org/10.1016/j.rechem.2023.101014  (IF: 2.5, Q2)
  10. Islam, M.T., Sarkar, C., Hossain, R., Bhuia, M.S., Mardare, I., Kulbayeva, M., Ydyrys, A., Calina, D., Habtemariam, S., Kieliszek, M., Sharifi-Rad, J., & Cho j, W. C. (2023). Therapeutic strategies for rheumatic diseases and disorders: targeting redox imbalance and oxidative stress. Biomedicine & Pharmacotherapy, 164, 114900. https://doi.org/10.1016/j.biopha.2023.114900 (IF: 6.9, Q1)
  11. Bhuia, M.S., Wilairatana, P., Chowdhury, R., Rakib, A.I., Kamli, H., Shaikh, A., Coutinho, H.D.M., & Islam, M.T. (2023). Anticancer Potentials of the Lignan Magnolin: A Systematic Review. Molecules, 28(9):3671. https://doi.org/10.3390/molecules28093671 (IF: 4.2, Q2)
  12. Bhuia, M.S., Siam, M.S.H., Ahamed, M.R., Roy, U.K., Hossain, M.I., Rokonuzzman, M., Islam, T., Sharafat, R., Bappi, M.H., Mia, M.N., Emamuzzaman, M., de Almeida, R.S., Coutinho, H.D.M., Raposo, A., Alturki, H.A., & Islam, M.T. (2023). Toxicity Analysis of Some Frequently Used Food Processing Chemicals Using Allium cepa Biomonitoring System. Biology 12, 637. https://doi.org/10.3390/biology12050637 (IF: 3.6, 5.7, Q1)
  13. Bhuia, M. S., Rahaman, M. M., Islam, T., Bappi, M. H., Sikder, M. I., Hossain, K. N., Akter, F., Al Shamsh Prottay, A., Rokonuzzman, M., Gürer, E. S., Calina, D., Islam, M. T., & Sharifi-Rad, J. (2023). Neurobiological effects of gallic acid: current perspectives. Chinese medicine, 18(1), 27. https://doi.org/10.1186/s13020-023-00735-7 (IF: 5.3, Q1)
  14. Bhuia, M. S., Islam, T., Rokonuzzman, M., Shamsh Prottay, A. A., Akter, F., Hossain, M. I., Chowdhury, R., Kazi, M. A., Khalipha, A. B. R., Coutinho, H. D. M., & Islam, M. T. (2023). Modulatory effects of phytol on the antiemetic property of domperidone, possibly through the D2 receptor interaction pathway: in vivo and in silico studies. 3 Biotech, 13(4), 116. https://doi.org/10.1007/s13205-023-03520-3 (IF: 2.6, Q3)
  15. Shahid, M. S., Ibrahim, M., Rahman, M. M., Islam, T., Bhuia, M. S., Zaman, S., & Islam, M. T. (2023). Phytochemical group test and pharmacological investigations of Persicaria barbata (L.) H. Hara. Phytopharmacology Research Journal, 2(1), 1-15. https://ojs.prjn.org/index.php/prjn/article/view/31
  16. Sonia, F. A., Islam, M. S., Akter, M. R., Bhuia, M. S., Ferdous, M. R., Tohfa, N. J., & Islam, M. T. (2023). Social status on conception, conception complications and uses of contraceptives: a survey in Khulna, Jashore and Dhaka districts in Bangladesh. European Journal of Biomedical, 10(1), 90-96. http://dx.doi.org/10.6084/m9.figshare.23815140 (IF:6)
  17. Hossain, M. I., Bhuia, M. S., Tohfa, N. J., Ahmed, M. R., Mukul, M. H., Foysal, M. S. I., Siam, M.S., Emamuzzaman, M., Sharafat, R., Islam, M.T., Coutinho, H.D.M., Alves, D.D., Araújo, I.M., Tahim, C.M., Lucetti, E.C.P., Silva, A.B. de B., & Islam, M. T. (2023). Evaluation of toxicity and clot lysis activity of thymol. Kariri Science, 01 (02). http://dx.doi.org/10.29327/2256856.1.2-9  
  18. Islam, M. T., Al Hasan, M. S., Hossain, M. S., Akbor, M. S., Chowdhury, A. K., & Bhuia, M. S. (2023). Pharmacists prescribe: hopes and challenges in modern healthcare management. Kariri Science, 01 (02). https://doi.org/10.29327/2256856.1.2-6

List of Publications- 2021

  1. Bhuia, M. S., Khalipha, A. B. R., Rahman, N., Rabbani, M. G., M., Siam, M.S.H., Hossain, M.S., Mondal, M., Munshi, M. H., Mia, M. M., & Hossen, S. (2021). In-silico drug design of Zeylanone and its derivatives against 6M0J for treatment of COVID-19 using molecular docking tools. International Journal of Evergreen Scientific Research, 04(02), 1-12. http://dx.doi.org/10.6084/m9.figshare.23815518
  2. Bhuia, M. S., Khalipha, A. B. R., Sakib, M. R., Prottay, A. A. S., Rahman, N., Hossain, M. I., Akter, K., Hossain, M.S., Siam, M.S.H., & Rahman, M. H. (2021). Drug design and development of alectinib against alk protein domain for treatment of lung cancer: an in-silico approach. International Journal of Evergreen Scientific Research, 3(2), 78-94. http://dx.doi.org/10.6084/m9.figshare.23815086
  3. Khalipha, A. B. R., Bhuia, M. S., M, Mondal., Hossain, M.S., Sakib, M. R., Prottay, A. A. S., Rahman, N., Rabbani, G., & Akter, K. (2021). IN-SILICO MOLECULAR DOCKING STUDY OF AFZELIN AND ITS DERIVATIVES AGAINST 6M0J FOR TREATMENT OF COVID-19. International Journal of Evergreen Scientific Research, 3(2), 62-67. https://doi.org/10.6084/m9.figshare.23815374